Selected Publications

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan N*, McKenzie S*, Beed P, English DF, Oldani S, Tukker JJ, Buzsáki G+, Schmitz D+.
Nat Commun. 2020 Apr 23;11(1):1947.

Loss of piccolo function in rats induces cerebellar network dysfunction and pontocerebellar hypoplasia type 3-like phenotypes.
Falck J, Bruns C, Hoffmann-Conaway S, Straub I, Plautz EJ, Orlando M, Munawar H, Rivalan M, Winter Y, Izsvák Z, Schmitz D, Hamra FK, Hallermann S, Garner CC*, Ackermann F*+.
J Neurosci. 2020 Apr 1;40(14):2943-2959.

Human cerebrospinal fluid monoclonal LGI1 autoantibodies increase neuronal excitability.
Kornau HC+, Kreye J, Stumpf A, Fukata Y, Parthier D, Sammons RP, Imbrosci B, Kurpjuweit S, Kowski AB, Fukata M, Prüss H*+, Schmitz D*.
Ann Neurol. 2020 Mar;87(3):405-418.

Calcium-independent exo-endocytosis coupling at small central synapses.
Orlando M, Schmitz D, Rosenmund C+, Herman MA+.
Cell Rep. 2019 Dec 17;29(12):3767-3774

Electrophysiological and molecular characterization of the parasubiculum.
Sammons RP+, Parthier D, Stumpf A, Schmitz D+.
J Neurosci. 2019 Nov 6;39(45):8860-8876.

Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function.
Jurek B*, Chayka M*, Kreye J, Lang K, Kraus L, Fidzinski P, Kornau HC, Dao LM, Wenke NK, Long M, Rivalan M, Winter Y, Leubner J, Herken J, Mayer S, Mueller S, Boehm-Sturm P, Dirnagl U, Schmitz D, Kölch M, Prüss H.+
Ann Neurol. 2019 Nov;86(5):656-670;

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.
Brockmann MM*, Maglione M*, Willmes CG*, Stumpf A, Bouazza BA, Velasquez LM, Grauel MK, Beed P, Lehmann M, Gimber N, Schmoranzer J, Sigrist SJ+, Rosenmund C+, Schmitz D+.
Elife. 2019 Sep 19;8

Single synapse indicators of impaired glutamate clearance derived from fast iGluu imaging of cortical afferents in the striatum of normal and Huntington (Q175) mice.
Dvorzhak A, Helassa N, Török K, Schmitz D, Grantyn R+.
J Neurosci. 2019 Feb 28. pii: 2865-18.

Estrus-cycle regulation of cortical inhibition.
Clemens AM, Lenschow C, Beed P, Li L, Sammons R, Naumann RK, Wang H, Schmitz D, Brecht M+.
Curr Biol. 2019 Feb 18;29(4):605-615.
 
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom SC+, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, Cao L, Yeste A, Tukker JJ, Quintana FJ, Imitola J, Witzel F, Schmitz D, Morkel M, Paul F*, Infante-Duarte C*, Khoury SJ*.
Nat Commun. 2019 Jan 15;10(1):217

Potassium channel-based optogenetic silencing.
Bernal Sierra YA*, Rost BR*, Pofahl M*, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R+, Schmitz D+.
Nat Commun. 2018 Nov 5;9(1):4611.

Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons.
Stumpf A, Parthier D, Sammons RP, Stempel AV, Breustedt J, Rost BR, Schmitz D+.
Neuropharmacology. 2018 Sep 1;139:217-225.

Involvement of mossy cells in sharp wave-ripple activity in vitro.
Swaminathan A, Wichert I, Schmitz D*, Maier N*+.
Cell Rep. 2018 May 29;23(9):2541-2549.

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
Subkhangulova A+, Malik AR, Hermey G, Popp O, Dittmar G, Rathjen T, Poy MN, Stumpf A, Beed PS, Schmitz D, Breiderhoff T, Willnow TE+.
EMBO Rep. 2018 Apr; 19(4).

Hippocampal ripple oscillations and inhibition-first network models: frequency dynamics and response to GABA modulators.
Donoso JR, Schmitz D, Maier N, Kempter R+.
J Neurosci. 2018 Feb 16. pii: 0188-17.

Optogenetic tools for subcellular applications in neuroscience.
Rost BR*+, Schneider-Warme F*, Schmitz D, Hegemann P.
Neuron. 2017 Nov 1;96(3):572-603.

Excitatory microcircuits within superficial layers of the medial entorhinal cortex.
Winterer J*, Maier N*, Wozny C, Beed P, Breustedt J, Evangelista R, Peng Y, D'Albis T, Kempter R, Schmitz D+.
Cell Reports. 2017 May 9;19:1110-1116.

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel MK*, Maglione M*, Reddy-Alla S*, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D+, Sigrist SJ+, Rosenmund C+.
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620.

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
Kreye J*, Wenke NK*, Chayka M, Leubner J, Murugan R, Maier N, Jurek B, Ly LT, Brandl D, Rost BR, Stumpf A, Schulz P, Radbruch H, Hauser AE, Pache F, Meisel A, Harms L, Paul F, Dirnagl U, Garner C, Schmitz D, Wardemann H, Prüss H+.
Brain. 2016 Oct;139(Pt 10):2641-2652.

Cell-specific synaptic plasticity induced by network oscillations.
Zarnadze S*, Bäuerle P*, Santos-Torres J, Böhm C, Schmitz D, Geiger JR, Dugladze T#, Gloveli T#+.
Elife. 2016 May 24;5.

Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus.
Stempel AV+, Stumpf A, Zhang HY, Özdoğan T, Pannasch U, Theis AK, Otte DM, Wojtalla A, Rácz I, Ponomarenko A, Xi ZX, Zimmer A, Schmitz D+.
Neuron. 2016 May 18;90(4):795-809.

Cellular and system biology of memory: timing, molecules, and beyond.
Korte M+, Schmitz D.
Physiol Rev. 2016 Apr;96(2):647-93.

Functional architecture of the rat parasubiculum.
Tang Q*, Burgalossi A*+, Ebbesen CL*, Sanguinetti-Scheck JI*, Schmidt H, Tukker JJ, Naumann R, Ray S, Preston-Ferrer P, Schmitz D, Brecht M+.
J Neurosci. 2016 Feb 17;36(7):2289-301.

Optogenetic acidification of synaptic vesicles and lysosomes.
Rost BR*+, Schneider F*, Grauel MK, Wozny C, G Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C.
Nat Neurosci. 2015 Dec;18(12):1845-52.

Serotonin attenuates feedback excitation onto O-LM interneurons.
Böhm C, Pangalos M, Schmitz D*, Winterer J*+.
Cereb Cortex. 2015 Nov;25(11):4572-83.

Functional diversity of subicular principal cells during hippocampal ripples.
Böhm C+, Peng Y, Maier N, Winterer J, Poulet JF, Geiger JR, Schmitz D+.
J Neurosci. 2015 Oct 7;35(40):13608-18.

Anatomical organization and spatiotemporal firing patterns of layer 3 neurons in the rat medial entorhinal cortex.
Tang Q, Ebbesen CL, Sanguinetti-Scheck JI, Preston-Ferrer P, Gundlfinger A, Winterer J, Beed P, Ray S, Naumann R, Schmitz D, Brecht M+, Burgalossi A+.
J Neurosci. 2015 Sep 9;35(36):12346-54.

Ryanodine receptor activation induces long-term plasticity of spine calcium dynamics.
Johenning FW*+, Theis AK*, Pannasch U, Rückl M, Rüdiger S, Schmitz D.
PLoS Biol. 2015 Jun 22;13(6):e1002181.

Retrograde signaling causes excitement.
Schmitz D+, Breustedt J, Gundlfinger A.
Neuron. 2014 Feb 19;81(4):717-9.

Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex.
Beed P, Gundlfinger A, Schneiderbauer S, Song J, Böhm C, Burgalossi A, Brecht M, Vida I, Schmitz D+.
Neuron. 2013 Sep 18;79(6):1197-207.

Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.
Kintscher M, Wozny C, Johenning FW, Schmitz D*, Breustedt J*+.
Nat Commun. 2013;4:2392.

Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples.
Pangalos M, Donoso JR, Winterer J, Zivkovic AR, Kempter R, Maier N*+, Schmitz D*+.
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4398-403.

Segregation of axonal and somatic activity during fast network oscillations.
Dugladze T, Schmitz D, Whittington MA, Vida I, Gloveli T+.
Science. 2012 Jun 15;336(6087):1458-61.

Cannabinoids disrupt hippocampal sharp wave-ripples via inhibition of glutamate release.
Maier N+, Morris G, Schuchmann S, Korotkova T, Ponomarenko A, Böhm C, Wozny C, Schmitz D+.
Hippocampus. 2012 Jun;22(6):1350-62.

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.
Schmeisser MJ*, Ey E*, Wegener S*, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM+.
Nature. 2012 Apr 29;486(7402):256-60.

GluK1 inhibits calcium dependent and independent transmitter release at associational/commissural synapses in area CA3 of the hippocampus.
Salmen B, Beed PS, Ozdogan T, Maier N, Johenning FW, Winterer J, Breustedt J, Schmitz D+.
Hippocampus. 2012 Jan;22(1):57-68.

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.
 Liu KS*, Siebert M*, Mertel S*, Knoche E*, Wegener S*, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Brückers J, Hell SW,Müller M, Davis GW, Schmitz D+, Sigrist SJ+.
Science. 2011 Dec 16;334(6062):1565-9.

Coherent phasic excitation during hippocampal ripples.
Maier N*, Tejero-Cantero A*, Dorrn AL, Winterer J, Beed PS, Morris G, Kempter R, Poulet JF*, Leibold C*, Schmitz D*+.
Neuron. 2011 Oct 6;72(1):137-52.

Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion.
Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J*+, Schmitz D*+.
J Cell Sci. 2011 Sep 15;124(Pt 18):3066-73.

Complementary sensory and associative microcircuitry in primary olfactory cortex.
Wiegand HF, Beed P, Bendels MH, Leibold C, Schmitz D*+, Johenning FW*+.
J Neurosci. 2011 Aug 24;31(34):12149-58.

Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus.
Winterer J, Stempel AV, Dugladze T, Földy C, Maziashvili N, Zivkovic AR, Priller J, Soltesz I, Gloveli T, Schmitz D+.
J Neurosci. 2011 Jun 8;31(23):8464-75.

Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.
Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M+.
Neuron. 2011 Apr 14;70(1):66-81.

Analysis of excitatory microcircuitry in the medial entorhinal cortex reveals cell-type-specific differences.
Beed P*, Bendels MH*, Wiegand HF, Leibold C, Johenning FW#+, Schmitz D#+.
Neuron. 2010 Dec 22;68(6):1059-66.

Autaptic cultures of single hippocampal granule cells of mice and rats.
Rost BR, Breustedt J, Schoenherr A, Grosse G, Ahnert-Hilger G, Schmitz D+.
Eur J Neurosci. 2010 Sep;32(6):939-47.

Detection of input sites in scanning photostimulation data based on spatial correlations.
Bendels MH, Beed P, Schmitz D, Johenning FW, Leibold C+.
J Neurosci Methods. 2010 Oct 15;192(2):286-95.

Munc13-2 differentially affects hippocampal synaptic transmission and plasticity.
Breustedt J, Gundlfinger A, Varoqueaux F, Reim K, Brose N, Schmitz D+.
Cereb Cortex. 2010 May;20(5):1109-20.

Dendritic compartment and neuronal output mode determine pathway-specific long-term potentiation in the piriform cortex.
Johenning FW+, Beed PS, Trimbuch T, Bendels MH, Winterer J, Schmitz D+.
J Neurosci. 2009 Oct 28;29(43):13649-61.

The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression.
Wozny C*+, Breustedt J*, Wolk F*, Varoqueaux F, Boretius S, Zivkovic AR, Neeb A, Frahm J, Schmitz D, Brose N, Ivanovic A.+
J Cell Sci. 2009 Mar 1;122(Pt 5):735-44.

Differential cAMP signaling at hippocampal output synapses.
Wozny C*+, Maier N*, Fidzinski P, Breustedt J, Behr J*, Schmitz D*+.
J Neurosci. 2008 Dec 31;28(53):14358-62.

A novel control software that improves the experimental workflow of scanning photostimulation experiments.
Bendels MH*+, Beed P*, Leibold C, Schmitz D*, Johenning FW*.
J Neurosci Methods. 2008 Oct 30;175(1):44-57.

Two different forms of long-term potentiation at CA1-subiculum synapses.
Wozny C+, Maier N, Schmitz D*, Behr J*.
J Physiol. 2008 Jun 1;586(Pt 11):2725-34

Differential modulation of short-term synaptic dynamics by long-term potentiation at mouse hippocampal mossy fibre synapses.
Gundlfinger A*, Leibold C*, Gebert K, Moisel M, Schmitz D*, Kempter R*+.
J Physiol. 2007 Dec 15;585(Pt 3):853-65.

Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels.
Gundlfinger A, Bischofberger J, Johenning FW, Torvinen M, Schmitz D*, Breustedt J*+.
J Physiol. 2007 Jul 1;582(Pt 1):263-77.

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.
Plath N*, Ohana O*, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bösl MR, Lipp HP, Grant SG, Bliss TV, Wolfer DP, Kuhl D+.
Neuron. 2006 Nov 9;52(3):437-44.

Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis.
Schuchmann S*, Schmitz D*, Rivera C, Vanhatalo S, Salmen B, Mackie K, Sipilä ST, Voipio J, Kaila K+.
Nat Med. 2006 Jul;12(7):817-23.

Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
Breustedt J, Schmitz D+.
J Neurosci. 2004 Nov 10;24(45):10093-8.

Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
Moore KA, Nicoll RA+, Schmitz D.
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14397-402.

Alpha1E-containing Ca2+ channels are involved in synaptic plasticity.
Breustedt J, Vogt KE, Miller RJ, Nicoll RA, Schmitz D+.
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12450-5.

Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.
Schmitz D*, Mellor J*, Breustedt J, Nicoll RA+.
Nat Neurosci. 2003 Oct;6(10):1058-63.

Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels.
Mellor J, Nicoll RA+, Schmitz D.
Science. 2002 Jan 4;295(5552):143-7.

Axo-axonal coupling: a novel mechanism for ultrafast neuronal communication.
Schmitz D+, Schuchmann S, Fisahn A, Draguhn A, Buhl EH, Petrasch-Parwez E, Dermietzel R, Heinemann U, Traub RD.
Neuron. 2001 Sep 13;31(5):831-40.

Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro.
Traub RD+, Bibbig R, Piechotta A, Draguhn R, Schmitz D.
J Neurophysiol. 2001 Mar;85(3):1246-56.

Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses.
Schmitz D, Mellor J, Nicoll RA+.
Science. 2001 Mar 9;291(5510):1972-6.

Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses.
Schmitz D, Frerking M, Nicoll RA+.
Neuron. 2000 Aug;27(2):327-38.

Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro.
Draguhn A+, Traub RD, Schmitz D, Jefferys JG.
Nature. 1998 Jul 9;394(6689):189-92.

 

* These authors contributed equally to this work.

# These authors also contributed equally to this work.

Corresponding authors